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Chromium contributes to normal macronutrient metabolism and to the maintenance of normal blood glucose levels

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In fact, NO at high levels inhibits heme insertion in hemoglobin, NO synthases, and heme thiolate enzymes, such as cytochrome P450s (CYP) in different manners (i.e., through the direct binding to the heme iron or to covalent modifications in heme transfer proteins) [147,148,149]

Hence, further study is warranted to confirm the antiproliferative effect of EGCG on leiomyoma via the COMT pathway

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